C. elegans Spatial Transcriptomics Service

Spatial transcriptomics is an advanced technology that profiles gene expression while preserving spatial context, enabling researchers to pinpoint where transcripts are enriched across anatomical regions and tissues. For C. elegans, spatially resolved transcriptomics offers a powerful way to link molecular programs to organismal phenotypes—supporting studies in development, neurobiology, reproduction, aging, and drug mechanism research. CD BioSciences provides C. elegans spatial transcriptomics services to global clients, delivering high-quality spatial gene expression maps and actionable interpretation.

Introduction to C. elegans Spatial Transcriptomics

Conventional bulk RNA-seq measures the average transcriptome of mixed cell populations, while single-cell RNA-seq provides cellular resolution but typically loses positional information. Spatial transcriptomics bridges this gap by capturing gene expression patterns along tissues/regions and reconstructing spatial maps that reflect biological architecture.

In C. elegans, spatial transcriptomics can be implemented through approaches such as RNA tomography (tomo-seq) based on serial cryosectioning and RNA sequencing, enabling the generation of high-resolution anteroposterior gene expression maps and the discovery of region- and tissue-associated transcriptional programs. Spatial transcriptomics datasets can also be integrated with existing single-cell resources to strengthen cell-type and region-level interpretation, providing a more intuitive way to connect genes, pathways, and phenotypes.

C. elegans neuron single-cell RNA sequencing Fig.1 Spatial transcriptomics enables spatially resolved gene expression mapping in C. elegans. (Ebbing, A., et al., 2018)

Our Services

CD BioSciences is committed to providing reliable and customized C. elegans Spatial Transcriptomics solutions that help researchers capture spatial gene expression patterns and decode region-specific biology. Our services include but are not limited to:

Tomo-seq (RNA Tomography) Spatial Transcriptomics

Whole-worm spatial transcriptome profiling based on serial cryosectioning followed by RNA-seq, enabling reconstruction of anteroposterior (A–P) expression maps. This package is ideal for discovering region-enriched genes, spatial expression gradients, and tissue-associated transcriptional programs across the worm body.

Section-Based Spatial Transcriptomics

Spatially resolved transcriptome profiling on worm sections using barcoded capture strategies (platform/workflow selected based on sample type and resolution requirements). This package is suitable when you need more localized spatial readouts and finer anatomical interpretation than A–P mapping alone.

Comparative Spatial Transcriptomics

Spatial profiling designed for between-group comparisons, supporting applications such as control vs. compound treatment, WT vs. mutant/transgenic strains, and time-course/dose-response. This package focuses on identifying spatial response signatures, region-specific pathway engagement, and tissue-associated toxicity or stress signals.

Workflow of Our Services

Why Choose CD BioSciences?

Advanced Technology

Experienced Experts

Customizable

Fast Turnaround

Spatial transcriptomics adds a critical dimension to transcriptome profiling by preserving anatomical context. Whether you are investigating developmental programs, tissue-specific regulation, or drug mechanisms, CD BioSciences provides high-quality C. elegans spatial transcriptomics services designed to advance your research goals. If you are interested in our services or have any questions, please feel free to contact us, and we look forward to collaborating on your attractive projects.

Reference

Ebbing, A., et al. (2018). Spatial Transcriptomics of C. elegans Males and Hermaphrodites Identifies Sex-Specific Differences in Gene Expression Patterns. Developmental cell, 47(6), 801–813.e6.

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