Metabolism has attracted a great deal of interest from researchers because it is the closest to the observed phenotype and is often one of the first foods to respond to a stimulus. Metabolomics analysis of C. elegans involves the comprehensive identification and quantification of metabolites present in its biological samples. This analysis can provide important information about the organism's physiological state, responses to different conditions or treatments, and the impact of genetic or environmental changes on its metabolism. With expertise and advanced technology, CD BioSciences offers comprehensive C. elegans metabolomics analysis services for a comprehensive understanding of C. elegans metabolism.

Introduction to Metabolomics in C. elegans

Metabolite concentrations are directly related to biochemical activity, and many biological processes depend on metabolism. Metabolomics is the study of small molecules (often referred to as metabolites), including lipid metabolism and glucose metabolism, in cells, tissues, or whole organisms. Metabolomics can be categorized into targeted metabolomics and untargeted metabolomics.

Targeted Metabolomics: The metabolites studied usually belong to a single class of compounds or a number of related classes of compounds or biochemical pathways, and the use of a single analytical technique may be
        sufficient.

Non-targeted Metabolomics: Characterizes a large number of metabolites by measuring a large number of metabolites simultaneously.

Fig. 1 Experimental workflow for combined metabolomics and lipidomic of the starvation response in C. elegans. (Dall K B, et al., 2021)

Because of their chemical complexity, metabolomics and lipidomic may represent the most complex of all "histologic" approaches. Metabolomics not only describes all metabolites in a biological system, but also allows for the study of interactions between an organism and its environment or between organisms. C. elegans metabolomics analytical methods include Nuclear Magnetic Resonance (NMR) spectroscopy, Direct Infusion Mass Spectrometry (DI-MS), Gas Chromatography Mass Spectrometry (GC-MS), and Liquid Chromatography Mass Spectrometry (LC-MS) or a combination thereof.

Our Services

As C. elegans research experts, CD BioSciences' team of experienced researchers and scientists are pioneers in C. elegans metabolomics and are confident in providing C. elegans metabolomics analysis services to clients worldwide. Utilizing an advanced and proven technology platform, our services include but are not limited to:

Why Choose CD BioSciences?

CD BioSciences utilizes the latest advances in metabolomics technology to analyze the various metabolites of C. elegans. With our experienced scientists and advanced and mature technology platform, we are confident that we can provide you with high-quality customized solutions based on your specific needs. We guarantee that all deliverables will undergo rigorous quality testing and be delivered on time. If you are interested in our services or have any questions, please feel free to contact us. We look forward to working with you on your attractive project.

Reference

1. Dall K B, Havelund J F, Harvald E B, et al. HLH‐30‐dependent rewiring of metabolism during starvation in C. elegans[J]. Aging Cell, 2021, 20(4): e13342

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