C. elegans has become a widely used model organism in biological research because of its small size, transparent body, well-defined anatomy, and relatively simple nervous system. By analyzing C. elegans morphology, researchers can gain insight into fundamental biological processes such as development, aging, behavior, reproduction, and disease. CD BioSciences has a team of experts specializing in C. elegans research, with extensive experience and sophisticated equipment, and is committed to providing high-quality, customized services that are confidently tailored to meet your specific needs.
Aging is the progressive physiological deterioration of an organism that causes morphological changes and increases the likelihood of death. Observing morphological changes in animals under a microscope is a valuable biomarker for aging research. Using C. elegans as an animal model for morphological measurements can help researchers study mutations, drugs, diet, environmental conditions, and other factors that affect aging. Analysis of C. elegans morphology includes the following:
Fig.1 A model for the regulation of body size by environmental factors in Caenorhabditis elegans. (Nagashima T, et al., 2017)
C. elegans is a valuable model for understanding the conserved biological mechanisms associated with human health and disease. As a leading custom service provider specializing in C. elegans research, CD BioSciences is committed to providing you with custom solutions. Our services for your C. elegans physiological analysis include, but are not limited to:
|Body Size Analysis||The perimeter of the lateral image of animals is measured and analyzed.|
|Body Length Analysis||Both aspect ratio and length-to-volume ratio, providing information on body proportions, growth, and body composition.|
|Pharynx Analysis||Analyze age-related changes in tissue appearance in the region of the head and pharynx.
The extent of deterioration categories: none, low, medium, high, and very high.
|Bacterial Content Analysis||Detect the number of bacteria in the pharynx and the anterior and posterior intestine.|
|Body Wall Muscles Analysis||Visualizing muscle morphology: GFP is expressed in the nuclei of body wall muscle cells,
Visualizing muscle structure: GFP is localized to the sarcomeres of the body wall muscles.
|Germline Analysis||Scoring germline disintegration of adult animals at 20°C. Five categories of germline deterioration:
Stage 1, the gonad is full sized and youthful in appearance;
Stage 2, the gonad is still intact, but shows slight signs of atrophy and deterioration;
Stage 3, the gonad shows clear atrophy and signs of impending disintegration;
Stage 4, fragmentation had occurred in gonad;
Stage 5, the gonad is occasionally seen.
|Vulval Morphology Analysis||Parameters such as the size, shape, and depth of invagination of the vulva of C. elegans are measured.|
CD Biosciences is your trusted partner for the analysis of C. elegans physiology, and we provide customized solutions for each of your specific needs. All our deliverables are subjected to rigorous quality testing and delivered on time. If you are interested in our services or have any questions, please feel free to contact us.