UV stress can have deleterious effects on organisms, including DNA damage, oxidative stress, and cellular dysfunction. Short wavelengths of light, especially ultraviolet light, cause avoidance behavior in C. elegans. This is mediated by a group of sensory neurons and is a protective mechanism to avoid lethal doses of UV light from sunlight. C. elegans, with its well-defined genetics and conserved cellular pathways, is an excellent model for studying the UV stress response. By utilizing our expertise and advanced technology, we have helped researchers gain insight into the molecular and cellular mechanisms of C. elegans' response to UV stress, which in turn provides valuable insights into organisms' responses to UV.

UV Stress in C. elegans

Light perception is critical to organisms, which have evolved various types of photoreceptors to detect light. For C. elegans, exposure to UV light leads to an escape behavior (avoidance behavior) and a pharyngeal pumping inhibition (acute cessation of feeding). In contrast to animals with external pigmentation, the worms are particularly vulnerable to the mutagenic effects of UV due to the transparent body that allows the penetration of lights. The LITE-1 taste receptor found in C. elegans, which is homolog as a UV-specific photoreceptor, and totally distinct from other photoreceptors in metazoans, microbes, and plants. The cellular response to UV irradiation in C. elegans is homologous to the mammalian DNA damage repair pathways, including:

• Homologs of DNA surveillance protein ataxia telangiectasia;
• RAD3-related kinase (ATR);
• CEP-1, a homologue of the tumor suppressor p53, plays a role in the behavioral response of the nervous system to UV light.

Fig.1 The C. elegans taste receptor homolog LITE-1 is a photoreceptor. (Gong J, et al., 2016)

Our Services

As a model organism commonly used in sensory perception, C. elegans detects and responds to a variety of sensory cues, such as mechanical forces (e.g., touch and stretch), chemicals (e.g., odorants and taste enhancers), and temperature. CD BioSciences specializes in C. elegans research, and our C. elegans UV stress analysis service is tailored to meet your specific research needs. The key features of our service are listed below:

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CD BioSciences is dedicated to providing the best services to accelerate the achievement of our customers' research goals. We standardize every procedure on our platform and can personalize services based on our customers' experiment objectives. If you are interested in our services or have any steady state, please feel free to contact us.

Reference

1. Gong J, Yuan Y, Ward A, et al. The C. elegans taste receptor homolog LITE-1 is a photoreceptor[J]. Cell, 2016, 167(5): 1252-1263. e10.

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