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| Host Species | Rabbit |
| Species Reactivity | C. elegans, Human, Mouse, Rat, Chicken, Fruit fly, Plat, Xenopus |
| Conjugate | Unconjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | This Histone H3 [ac Lys23] antibody was raised against synthetic acetylated peptide surrounding Lysine 23 of human Histone H3. |
| Format | BSA Free |
| Cellular Localization | Nucleus, Chromosome |
| Purification | 0.025 mg |
| Availability | Made-to-order |
| Target Name | H3C14 |
| Gene ID | 126961 |
| UniProt ID | Q71DI3 |
| Introduction | Chromatin is an arrangement of DNA and proteins which form chromosomes. Chromatin is formed from nucleosomes, which are comprised of a set of four histone proteins (H2A, H2B, H3, H4) wrapped with DNA. Chromatin is very dynamic, where post-translational modifications can regulate DNA to be copied, transcribed, or repaired. Histones are nuclear proteins responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Changes in chromatin structure play a large role in the regulation of transcription. The chromatin fibers are compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. Posttranslational modifications such as acetylation of core histones regulates gene expression, thus altering protein function and regulation. Histone H3 is primarily acetylated at lysines 9, 14, 18, and 23 and have a theoretical molecular weight of 15 kDa. Acetylation at lysine 9 and 14 appears to control histone deposition, chromatin assembly and active transcription. Methylation of arginine residues within histone H3 has also been linked to transcription regulation. Histone H31 has been linked to various types of cancer as a biomarker through the aberrant expression of histone deacetylase (HDAC) enzymes and changes to chromatins. |
| Application | DB, WB |
| Application Notes | DB: 1/1000 WB: 1/500 |
| MW (Target) | 15 kDa |
| Shipping | Store at 4 °C: short-term (1-2 weeks) Store at -20 °C: long-term and future use |
| Storage | Affinity purification with immunogen |
| Buffer | PBS, 30% Glycerol |
For Research Use Only. Not For Clinical Use.Related Products
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