Anti-Histone H4 [Dimethyl Lys20] Polyclonal Antibody
Cat: CDC-106

Product Details

Host Species	Rabbit
Species Reactivity	C. elegans, Human, Mouse, Rat, Chicken, Fruit fly, Plat, Xenopus
Conjugate	Unconjugated
Clonality	Polyclonal
Isotype	IgG
Immunogen	Synthetic dimethylated peptide surrounding Lysine 20 of human Histone H4.
Format	BSA Free
Cellular Localization	Nucleus, Chromosome
Purification	0.025 mg
Availability	Made-to-order

Target Information

Target Name	HIST4H4
Gene ID	103218674
UniProt ID	P62805
Introduction	When K20 is di-methylated on H4, the downstream effect is silencing of genes. This modification is also necessary and sufficient for 53BP1 binding, which is a prerequisite for DNA repair, a highly conserved mechanism. H4K20me2 is associated with hypoacetylation, and inactivation of certain genes. NSD1 and Suv420h1/2 trigger the dimethylation of K20, but only after SET8 catalyzes the mono-methylation of the same lysine, indicating a complex regulation of this modification that can so seriously affect replication and stability of genomic information.

Usage

Application	ChIP, DB, ICC/IF, WB
Application Notes	ChIP: 2-5 µg per million cells DB: 1/1000 ICC/IF: 1/50 WB: 1/2000
MW (Target)	13 kDa

Shipping & Handling

Shipping	Store at 4 °C: short-term (1-2 weeks) Store at -20 °C: long-term and future use
Storage	Affinity purification with immunogen
Buffer	PBS, 30% Glycerol

For Research Use Only. Not For Clinical Use.

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